Cannabinoids represent a diverse array of chemical compounds inherent to the Cannabis sativa plant, Most commonly known as just cannabis. These compounds engage with cannabinoid receptors dispersed throughout the body and brain, eliciting effects akin to those induced by the cannabis plant itself.
Cannabinoids can be categorized into three primary classes:
- Phytocannabinoids â These compounds derive from the cannabis plant and encompass well-known substances like THC (Delta-9 tetrahydrocannabinol) and CBD (cannabidiol). Over a hundred distinct phytocannabinoids have been discovered, each manifesting unique interactions with the human bodyâs central nervous system.
- Endocannabinoids â These naturally synthesized compounds within the body play a pivotal role in the endocannabinoid system (ECS). Examples include anandamide and 2-arachidonylglycerol (2-AG). They serve as intercellular messengers regulating critical functions such as mood, memory, sleep, and appetite.
- Synthetic cannabinoids â These artificially produced substances are engineered to replicate the effects of natural cannabinoids. While often employed in research and medical contexts, they also present risks of abuse and adverse reactions.
Cannabinoids exert their influence by binding to cannabinoid receptors distributed across the central nervous system and other bodily systems. The predominant receptor types are CB1 and CB2. Cannabinoidsâ effects can vary based on the specific receptors engaged and the neural circuits activated. For instance, cannabinoids may impact memory, cognition, mood, pain perception, and appetite.
Beyond THC and CBD, cannabinoids like CBG (cannabigerol), CBC (cannabichromene), and CBN (cannabinol) also contribute to cannabisâ overall effects. Many believe cannabinoids have potential for therapeutic applications across various medical conditions. However, at this time, further formal scientific investigation is warranted to prove or refute the reputation that precedes cannabinoids.